Doxycycline has distinct apicoplast-specific mechanisms of antimalarial activity
نویسندگان
چکیده
منابع مشابه
The apicoplast as an antimalarial drug target.
Resistance to commonly used malaria drugs is spreading and new drugs are required urgently. The recent identification of a relict chloroplast (apicoplast) in malaria and related parasites offers numerous new targets for drug therapy using well-characterized compounds. The apicoplast contains a range of metabolic pathways and housekeeping processes that differ radically to those of the host ther...
متن کاملThiostrepton and derivatives exhibit antimalarial and gametocytocidal activity by dually targeting parasite proteasome and apicoplast.
Ribosome-targeting antibiotics exert their antimalarial activity on the apicoplast of the malaria parasite, an organelle of prokaryote origin having essential metabolic functions. These antibiotics typically cause a delayed-death phenotype, which manifests in parasite killing during the second replication cycle following administration. As an exception, treatment with the antibiotic thiostrepto...
متن کاملTetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum.
Tetracyclines are effective but slow-acting antimalarial drugs whose mechanism of action remains uncertain. To characterize the antimalarial mechanism of tetracyclines, we evaluated their stage-specific activities, impacts on parasite transcription, and effects on two predicted organelle targets, the apicoplast and the mitochondrion, in cultured Plasmodium falciparum. Antimalarial effects were ...
متن کاملAnticancer Properties of Distinct Antimalarial Drug Classes
We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines. Three classes of drugs: artemisinins, synthetic peroxides and DHFR (dihydrofolate reductase) inhibitors effected potent inhibition of proliferation with IC50s in the nM- low µM range, whereas a DHODH (dihydroorotate dehydrogenase) and a ...
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What do you think is the big question to be answered in your field? Our big question is consciousness. This is on a par with the nature of matter, space, and time, and the origin of the universe. It was once a dark, unfundable subject but thanks to the efforts of a few like Christof Koch, Francis Crick, Bernie Baars, Dan Dennett, Stan Dehaene and others, it has taken its deserved central place ...
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ژورنال
عنوان ژورنال: eLife
سال: 2020
ISSN: 2050-084X
DOI: 10.7554/elife.60246